Dean Koontz's Frankenstein Prodigal Son, City of Night, Dead and Alive

Dead and alive - Deucalion's centuries-old history began as the original manifestation of a soulless vision--and it is fated to end in the ultimate confrontation between a damned creature and his mad creator, Victor Helios. But first they must face a monstrosity not even Victor's malignant mind could have conceived--an indestructible entity that steps out of humankind's collective nightmare with powers, and a purpose, beyond imagining that threatens to destroy New Orleans and the future of humanity.